Research Papers
- Leclair NK, Brugiolo M, Walawalkar I, Yurieva M, Kang HG, Englander RP, Ryan M, Heffner C, McDonough JA, Skarnes WC, Murray S, Anczuków O# (2026). Splicing of ultraconserved poison exons controls mitotic fidelity and stem cell viability. bioRxiv 2026.05.19.726407. https://doi.org/10.64898/2026.05.19.726407. PMC13228269. #Corresponding author.
- Cady MA, Aggarwa A, Stevers NO, Zakimi N, Kongpracha P, Liu I, Zhou Y, Mitschka S, Mirchia K, Leclair NK, Nguyen MP, Coukos JS, Braman BC, Shamdasani-Sen S, Choi B, Chantousti N, Hong C, Englander RP, Frankus J, Sinha D, Phillips JJ, Karner H, Liu SJ, Choudhury A, Krogan NJ, Costello JF, Anczukow O, Toedebusch C, Mazcko CN, Dickinson PJ, LeBlanc AK, Schmitt AM, Goodarzi H, Swaney DL, Raleigh DR (2026). A proteogenomic RNA processing mechanism drives sex differences in meningioma. Research Square, https://doi.org/10.21203/rs.3.rs-9675139/v1. PMC13252561.
- Kang HG, Yurieva M, Brugiolo M, Chuang J, Anczukow O#. SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing Events. bioRxiv 2025.10.01.679902. https://www.biorxiv.org/content/10.1101/2025.10.01.679902v1 PMC12621892. #Corresponding author.
- Horvath M, Kang HG, Wu T, Aiken E, Castaneda DC, Akkurt S, Marches F, Anczuków O, Palucka K, Oh J (2025). Host-specific bacterial modulation of airway gene expression and alternative splicing. mSphere, e00577-25.
- Englander RP, Brugiolo M, Wu TC, Kostich M, Leclair NK, Park SH, Banchereau J, Yu P, Salner A, Banchereau R, Palucka K#, Anczuków O# (2025). Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer. bioRxiv 2025.08.19.671121. #Corresponding author.
- Nesta A, Veiga DFT, Banchereau J, Anczuków O, Beck C (2025). Alternative splicing of transposable elements in human breast cancer. Mobile DNA, 16 (1), 6.
- Rubinstein JC, Domanskyi S, Sheridan TB, Sanderson B, Park SH, Kaster J, Li H, Anczukow O, Herlyn M, Chuang JH (2025). Spatiotemporal Profiling Defines Persistence and Resistance Dynamics during Targeted Treatment of Melanoma. Cancer Res, 85 (5): 987–1002.
- Leclair NK, Brugiolo M, Park S, Devoucoux M, Urbanski L, Angarola BL, Yurieva M, & Anczuków O# (2025). Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects. Nature communications, 16(1), 1670. #Corresponding author.
- Angarola BL*, Sharma S*, Katiyar N, Kang HG, Nehar-Belaid D, Park S, Gott R, Eryilmaz GN, LaBarge M, Palucka K, Chuang JH, Korstanje R, Ucar D#, Anczuków O# (2025). Comprehensive single cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer. Nature Aging,Jan;5(1):122-143. *equal contribution. #Corresponding author.
- Karginov TA, Ménoret A, Leclair NK, Chandiran K, Suarez-Ramirez JE, Karlinsey K, O’Neill RJ, Murphy PA, Adler AJ, Cauley LS, Anczuków O, Zhou B, Vella AT (2024). Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation. Science, 385(6714):eadj1979.
- Karlebach G, Steinhaus R, Danis D, Devoucoux M, Anczuków O, Sheynkman G, Seelow D, Robinson PN. (2024). Alternative splicing is coupled to gene expression in a subset of variably expressed genes. npj Genomic Medicine, 9:54. PMC10312658.
- Leclair NK, Chen WC, Zakimi Naomi, Choudhury A, Magill S, Shen E, Bulsara KR, Raleigh D#, Anczuków O# (2024). RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups. Neuro-oncology, Aug 2:noae150. #Corresponding author.
- Leclair NK, Chen WC, Zakimi Naomi, Raleigh D#, Anczuków O# (2024). The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas. Acta Neuropathologica, 148(1):28. PMC11343784. #Corresponding author.
- Nesta AV, Veiga DFT, Banchereau J, Anczukow O, Beck CR (2024). Alternative splicing of transposable elements in human breast cancer. bioRxiv,
- Rubinstein JC*, Domanskyi S*, Sheridan TB, Sanderson BJ, Park S, Kaster J, Li H, Anczukow O, Herlyn M, Chuang JH (2024). Spatiotemporal profiling defines persister and resistance signatures in targeted treatment of melanoma. Cancer Research, 2024 Dec 19
- Mukashyaka P, Kumar P, Mellert DJ, Nicholas S, Noorbakhsh J, Brugiolo M, Anczukow O, Liu ET, Chuang JH (2023). High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos. Nat Commun, 14(1):8406. PMC10730814.
- Urbanski L, Brugiolo M, Park S, Angarola BL, Leclair NK, Palmer P, Keshari Sahu S, Anczuków O# (2022). MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors. Cell Reports 41(8), 11704. PMC9731204. #Corresponding author.
- Veiga DFT*, Nesta A*, Zhao Z, Deslattes May A, Huynh R, Rossi R, Wu TC, Palucka K, Anczukow O#, Beck CR# and Banchereau J# (2022). Long-read isoform sequencing reveals survival-associated splicing in breast cancer. Sciences Advances, 8(3):eabg6711. PMC8769553. *equal contribution, #Corresponding author.
- Jun Y*, Suh YS*, Park S, Kim JI, Lee S, Lee WP#, Anczuków O#, Yang HK#, Lee C# (2022). Comprehensive Analysis of Alternative Splicing in Gastric Cancer Identifies Epithelial-Mesenchymal Transition Subtypes Associated with Survival. Cancer Research, 15;82(4):543-555. PMID: 34903603. *equal contribution, #Corresponding author.
- Rao C, Svoboda RA, Southekal S, Vieira HM, Huisman DH, Chatterjee D, Guda C, Fisher KW, Anczuków O, Lewis RE. Post-transcriptional control of SRSF9 promotes the epithelial-to-mesenchymal transition (EMT) in colorectal cancer cells. bioRxiv.
- Miyano M*, Sayaman RW*, Shalabi S, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak M, Stampfer MR, Seewaldt VE, LaBarge MA (2021). Breast specific molecular clocks comprised of ELF5 expression and promoter methylation identify individuals susceptible to cancer initiation. Cancer Prev Res, 14(8):779-794. PMC8338914. *equal contribution.
- Leclair NK, Brugiolo M, Urbanski L, Lawson S, Thakar K, Yurieva M, George J, Hinson JT, Cheng A, Graveley BR, Anczuków O# (2020). Poison exon splicing regulates a coordinated network of SR protein expression during differentiation and tumorigenesis. Molecular Cell, 80(4):648-665.e9. PMC7680420. #Corresponding author.
- Karlebach G, Hansen P, Veiga DFT, Steinhaus R, Danis D, Li S, Anczuków O, Robinson PN (2020). HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis. Genome Biol, 21, 171. PMID: 32660516.
- Sinnakannu JR, Kian Lee L, Cheng S, Li J, Yu M, Tan SP, Ong CCH, Li H, Anczuków O, Krainer ARK, Roca X, Rozen SG, Iqbal J, Yang H, Chuah C, S Ong ST (2020). SRSF1 mediates cytokine-induced tyrosine kinase inhibitor-resistance in chronic myeloid leukemia. Leukemia, Jul;34:1787-1798. PMID: 32051529.
- Karlebach G, Veiga DFT, Deslattes Mays A, Kesarwani AK, Danis D, Kararigas G, Zhang XA, George J, Ananda G, Steinhaus R, Hansen P, Seelow D, Bizon C, Boyles R, Ball C, McMurry JA, Haendel MA, Yang J, Oprea T, Mukerji M, Anczuków O, Banchereau J, Robinson PN. The impact of sex on alternative splicing. bioRxiv.
- Park S*, Brugiolo M*, Akerman M*, Das S*, Urbanski L, Geier A, Kesarwani AK, Fan M, Leclair NK, Lin KT, Hua L, Hu I, George J, Muthuswamy SK, Krainer AR#, Anczukow O# (2019). Differential functions of splicing factors in mammary transformation and breast cancer metastasis. Cell Reports, 29(9), 2672-2688.e7. PMC6936330. *equal contribution. #Corresponding author.
- Anczuków O*, Akerman M*, Cléry A, Wu J, Shen C, Shirole HN, Raimer A, Sun S, Jensen MA, Hua Y, Allain FHT, Krainer AR (2015). SRSF1-regulated alternative splicing in breast cancer. Molecular Cell, 60(1), 105-117. PMC4597910. *equal contribution.
- Cléry A, Sinha R, Anczuków O, Corrionero A, Moursy A, Daubner G, Valcárcel J, Krainer AR, Allain F (2013). Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. PNAS, 110:E2802-11. PMC3725064.
- Wu J, Anczuków O, Krainer AR, Zhang MQ, Zhang C (2013). OLego: Fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acid Research, 41:5149-5163. PMC3664805.
- Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. (2012). The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural Molecular Biology, 19:220-8. PMC3272117.
- Das S, Anczuków O, Akerman M, Krainer AR. (2012). Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Reports, 1:110–117. PMC3334311.
- Anczuków O, Buisson M, Leone M, Coutanson C, Lasset C, Calender A, Sinilnikova OM, Mazoyer S. (2012). BRCA2 Deep Intronic Mutation Causing Activation of a Cryptic Exon: Opening Towards a New Preventive Therapeutic Strategy. Clinical Cancer Research, 18:4903-4909. PMID: 22753590.
- Anczuków O, Ware MD, Buisson M, Zetoune AB, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S (2008). Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? Human Mutation, 29:65-73. PMID: 17694537.
- Anczuków O, Buisson M, Salles MJ, Triboulet S, Longy M, Lidereau R, Sinilnikova OM, Mazoyer S (2008). Unclassified Variants Identified in BRCA1 Exon 11: Consequences on Splicing. Genes, Chromosomes and Cancer, 47:418-26. PMID: 18273839.
- Zetoune AB, Fontaniere S, Magnin D, Anczuków O, Buisson M, Zhang CZ, Mazoyer S (2008). Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues. BMC Genetics, 9:83. PMC2607305.
- Buisson M, Anczuków O, Zetoune AB, Ware MD, Mazoyer S (2006). The 185delAG mutation in the BRCA1 gene triggers translation reinitiation at a downstream AUG codon. Human Mutation, 27:1024-9. PMID: 16941470.
- Sinilnikova OM, Ginolhac SM, Magnard C, Leone M, Anczuków O, Hughes D, Moreau K, Thompson D, Coutanson C, Hall J, Romestaing P, Gerard JP, Bonadona V, Lasset C, Goldgar DE, Joulin V, Venezia ND, Lenoir GM (2004). Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility. Carcinogenesis, 25: 2417-24. PMID: 15333468.
Reviews and Perspective Papers
- Anczuków O#, Allain F, Angarola BL, Black B, Brooks A, Cheng C, Conesa A, Crosse E, Guccione E, Lu SX, Neugebauer KM, Sehgal P, Song X, Tothova Z, Valcárcel J, Eyras E, Weeks KM, Yeo GW, Thomas-Tikhonenko A# (2024). Steering research on mRNA splicing in cancer towards clinical translation. Nat Rev Cancer, 24, 887–905. #Corresponding author.
- Anczuków O#, Airhart S, Chuang JH, Coussens LM, Kuchel GA, Korstanje R, Li S, Lucido AL, McAllister SS, Politi K, Polyak K, Ratliff T, Ren G, Trowbridge JJ, Ucar D, Palucka K# (2023). Challenges and opportunities for modeling aging and cancer. Cancer Cell, 41(4):641-645. PMC10185379. #Corresponding author.
- Bradley RK#, Anczuków O# (2023). RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer, 23(3):135-155. PMC10132032. #Corresponding author.
- Leclair NK, Anczuków O# (2022). Poisoning’ of the transcriptome by ultraconserved elements. Nat Rev Mol Cell Biol. 23(12):777. PMC9793964. #Corresponding author.
- Angarola BL, Anczuków O# (2021). Splicing alterations in healthy aging and disease. WIREs RNA, 12(4):e1643.PMC8195850. #Corresponding author.
- Urbanski L, Leclair NK, Anczuków O# (2018). Alternative-splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics. Wires RNA, 9(4):e1476. PMC6002934. #Corresponding author.
- Anczuków O and Krainer AR (2016). Splicing-factor alterations in cancers. RNA, 22:1285-301. PMC4986885.
- Anczuków O and Krainer AR (2015). The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Medicine, 7:107. PMC4618744.
Patents
Modified Antisense Oligonucleotides Targeting Splicing Factors. Anczukow O, Leclair N. US 63/110,225 (11/05/2020).
Compositions And Methods For Treating Meningioma. Anczukow O, Leclair N. US 63/685,365 (08/21/2024)